Protein profile

VK055_3861

phosphocarrier, HPr family protein

Genome: KpATCC43816

Gene: AIK82411.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW82
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Amino acids 90
Annotations 2
Features 23
PDB binders 0
Druggability 0.444

Overview

Basic information about this protein and its source genome.

Accession
VK055_3861
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82411.1
Status
annotated
Amino acids
90
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
58.427
DEG E-value
2.66e-35
Localization
Cytoplasmic
ColabFold pLDDT
87.99

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.444
Structure A0A0H3GW82
Pocket Pocket 3
P2Rank
Structure A0A0H3GW82
Pocket No pockets
ColabFold model
FPocket 0.192 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
2 90 ProSiteProfiles PS51350 PTS HPR domain profile.
2 90 InterPro IPR000032 Phosphocarrier protein HPr-like
1 89 PANTHER PTHR33705 PHOSPHOCARRIER PROTEIN HPR
1 85 Gene3D G3DSA:3.30.1340.10 -
1 85 InterPro IPR035895 HPr-like superfamily
41 56 ProSitePatterns PS00589 PTS HPR domain serine phosphorylation site signature.
41 56 InterPro IPR002114 Phosphotransferase system, HPr serine phosphorylation site
4 84 NCBIfam TIGR01003 HPr family phosphocarrier protein
4 84 InterPro IPR000032 Phosphocarrier protein HPr-like
14 21 ProSitePatterns PS00369 PTS HPR domain histidine phosphorylation site signature.
14 21 InterPro IPR001020 Phosphotransferase system, HPr histidine phosphorylation site
6 83 CDD cd00367 PTS-HPr_like
6 83 InterPro IPR000032 Phosphocarrier protein HPr-like
1 85 FunFam G3DSA:3.30.1340.10:FF:000002 PTS phosphocarrier protein NPr
55 72 PRINTS PR00107 Phosphocarrier protein signature
55 72 InterPro IPR000032 Phosphocarrier protein HPr-like
40 55 PRINTS PR00107 Phosphocarrier protein signature
40 55 InterPro IPR000032 Phosphocarrier protein HPr-like
14 30 PRINTS PR00107 Phosphocarrier protein signature
14 30 InterPro IPR000032 Phosphocarrier protein HPr-like
4 84 Pfam PF00381 PTS HPr component phosphorylation site
4 90 SUPERFAMILY SSF55594 HPr-like
4 90 InterPro IPR035895 HPr-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW82
AlphaFold — — full sequence — Viewing
ColabFold VK055_3861
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.444
1 0.095
4 0.026
2 0.014