Protein profile

VK055_3921

BON domain protein

Genome: KpATCC43816

Gene: AIK82469.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW29
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Amino acids 191
Annotations 0
Features 22
PDB binders 0
Druggability 0.442

Overview

Basic information about this protein and its source genome.

Accession
VK055_3921
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82469.1
Status
annotated
Amino acids
191
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
50.262
DEG E-value
7.47e-63
Localization
Periplasmic
ColabFold pLDDT
88.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.442
Structure A0A0H3GW29
Pocket Pocket 4
P2Rank 0.019
Structure A0A0H3GW29
Pocket Pocket 1
ColabFold model
FPocket 0.143 · Pocket 1
P2Rank 0.019 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 114 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
124 191 ProSiteProfiles PS50914 BON domain profile.
124 191 InterPro IPR007055 BON domain
3 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 19 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
46 113 Pfam PF04972 BON domain
46 113 InterPro IPR007055 BON domain
124 189 Pfam PF04972 BON domain
124 189 InterPro IPR007055 BON domain
46 115 ProSiteProfiles PS50914 BON domain profile.
46 115 InterPro IPR007055 BON domain
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
7 190 PANTHER PTHR34606 BON DOMAIN-CONTAINING PROTEIN
22 191 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
51 114 SMART SM00749 bon
51 114 InterPro IPR014004 Transport-associated and nodulation domain, bacteria
129 191 SMART SM00749 bon
129 191 InterPro IPR014004 Transport-associated and nodulation domain, bacteria
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW29
AlphaFold — — full sequence — Viewing
ColabFold VK055_3921
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.442
2 0.017
1 0.0
5 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.56 0.019