Protein profile

VK055_4004

urease subunit beta

Genome: KpATCC43816

Gene: AIK82551.1 ureB Structure source: Experimental + ColabFold UniProt W9BBU3
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Amino acids 106
Annotations 4
Features 12
PDB binders 0
Druggability 0.111

Overview

Basic information about this protein and its source genome.

Accession
VK055_4004
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82551.1 ureB
Status
annotated
Amino acids
106
Structure source
Experimental + ColabFold
EC
3.5.1.5
GO
GO:0043419 The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. GO:0035550 A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide). GO:0009039 Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
56.863
DEG E-value
3.52e-37
Localization
Cytoplasmic
ColabFold pLDDT
96.29

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.111
Structure 8HCN
Pocket Pocket 3
P2Rank
Structure 8HCN
Pocket No pockets
ColabFold model
FPocket 0.129 · Pocket 1
P2Rank 0.002 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 354 / 4744 genomes with a hit
Normalized 0.075

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0043419 The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2.
  • GO:0035550 A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).
  • GO:0009039 Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 102 PANTHER PTHR33569 UREASE
1 101 CDD cd00407 Urease_beta
1 101 InterPro IPR002019 Urease, beta subunit-like
3 99 Pfam PF00699 Urease beta subunit
3 99 InterPro IPR002019 Urease, beta subunit-like
1 101 Hamap MF_01954 Urease subunit beta [ureB].
1 101 NCBIfam TIGR00192 urease subunit beta
1 104 SUPERFAMILY SSF51278 Urease, beta-subunit
1 104 InterPro IPR036461 Urease, beta subunit superfamily
1 106 Gene3D G3DSA:2.10.150.10 Urease, beta subunit
1 106 InterPro IPR036461 Urease, beta subunit superfamily
1 106 FunFam G3DSA:2.10.150.10:FF:000001 Urease subunit beta

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 8HCN
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold VK055_4004
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
45 0.924
3 0.821
47 0.8
7 0.672

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.0 0.864
2 16.33 0.776
3 14.14 0.713
4 13.01 0.671
5 12.75 0.661