Protein profile

VK055_4138

yecA family protein

Genome: KpATCC43816

Gene: AIK82684.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GV75
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Amino acids 164
Annotations 1
Features 12
PDB binders 0
Druggability 0.459

Overview

Basic information about this protein and its source genome.

Accession
VK055_4138
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82684.1
Status
annotated
Amino acids
164
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.415
DEG E-value
6.3e-98
Localization
Cytoplasmic
ColabFold pLDDT
91.03

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.459
Structure A0A0H3GV75
Pocket Pocket 1
P2Rank 0.03
Structure A0A0H3GV75
Pocket Pocket 1
ColabFold model
FPocket 0.546 · Pocket 2
P2Rank 0.022 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 111 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 164 FunFam G3DSA:1.20.120.740:FF:000001 UPF0149 protein YgfB
1 149 Pfam PF03695 Uncharacterised protein family (UPF0149)
1 149 InterPro IPR011978 YgfB-like
1 164 PANTHER PTHR37528 UPF0149 PROTEIN YGFB
1 148 SUPERFAMILY SSF101327 YgfB-like
1 148 InterPro IPR036255 YgfB-like superfamily
1 162 Hamap MF_00346 UPF0149 protein YgfB [ygfB].
1 162 InterPro IPR011978 YgfB-like
2 138 NCBIfam TIGR02292 UPF0149 family protein
2 138 InterPro IPR011978 YgfB-like
1 164 Gene3D G3DSA:1.20.120.740 YgfB uncharacterised protein family UPF0149, PF03695
1 164 InterPro IPR036255 YgfB-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GV75
AlphaFold — — full sequence — Viewing
ColabFold VK055_4138
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.459
6 0.012
2 0.001
8 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.86 0.03
2 1.47 0.017
3 1.43 0.016