Protein profile

VK055_4149

DSBA-like thioredoxin domain protein

Genome: KpATCC43816

Gene: AIK82695.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H2M9
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Amino acids 203
Annotations 0
Features 18
PDB binders 0
Druggability 0.503

Overview

Basic information about this protein and its source genome.

Accession
VK055_4149
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82695.1
Status
annotated
Amino acids
203
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.503
Structure A0A0H3H2M9
Pocket Pocket 5
P2Rank
Structure A0A0H3H2M9
Pocket No pockets
ColabFold model
FPocket 0.352 · Pocket 7
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 59 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
54 72 ProSitePatterns PS00194 Thioredoxin family active site.
54 72 InterPro IPR017937 Thioredoxin, conserved site
46 194 CDD cd03023 DsbA_Com1_like
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
21 203 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
32 194 SUPERFAMILY SSF52833 Thioredoxin-like
32 194 InterPro IPR036249 Thioredoxin-like superfamily
1 18 SignalP_EUK SignalP-noTM SignalP-noTM
40 194 Pfam PF13462 Thioredoxin
40 194 InterPro IPR012336 Thioredoxin-like fold
8 198 ProSiteProfiles PS51352 Thioredoxin domain profile.
8 198 InterPro IPR013766 Thioredoxin domain
1 18 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
16 201 Gene3D G3DSA:3.40.30.10 Glutaredoxin
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
46 195 PANTHER PTHR35272 THIOL:DISULFIDE INTERCHANGE PROTEIN DSBC-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H2M9
AlphaFold — — full sequence — Viewing
ColabFold VK055_4149
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.016
9 0.009
1 0.001
6 0.001