Protein profile

VK055_4187

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK82732.1 Structure source: AlphaFold + ColabFold UniProt A0A383PBH0
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Amino acids 317
Annotations 3
Features 32
PDB binders 0
Druggability 0.678

Overview

Basic information about this protein and its source genome.

Accession
VK055_4187
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82732.1
Status
annotated
Amino acids
317
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
34.643
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.678
Structure A0A383PBH0
Pocket Pocket 6
P2Rank 0.467
Structure A0A383PBH0
Pocket Pocket 1
ColabFold model
FPocket 0.69 · Pocket 6
P2Rank 0.559 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 52 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
111 305 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
111 305 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
181 203 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
93 307 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
93 307 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
5 308 PANTHER PTHR30465 INNER MEMBRANE ABC TRANSPORTER
93 296 CDD cd06261 TM_PBP2
93 296 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
93 115 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 92 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
89 298 SUPERFAMILY SSF161098 MetI-like
89 298 InterPro IPR035906 MetI-like superfamily
23 32 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 32 Phobius SIGNAL_PEPTIDE Signal peptide region
7 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
202 283 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
135 160 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
180 201 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
135 157 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 16 SignalP_EUK SignalP-TM SignalP-TM
115 134 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
284 308 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
284 306 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
161 179 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 74 Pfam PF19300 Binding-prot-dependent transport system membrane comp, N-term
7 74 InterPro IPR045621 ABC transporter type 1, GsiC-like, N-terminal domain
309 317 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
82 310 Gene3D G3DSA:1.10.3720.10 -
82 310 InterPro IPR035906 MetI-like superfamily
93 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A383PBH0
AlphaFold — — full sequence — Viewing
ColabFold VK055_4187
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.678

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.1 0.543
2 6.47 0.327
3 3.09 0.103
4 1.5 0.021