Protein profile

VK055_4195

urease subunit beta

Genome: KpATCC43816

Gene: AIK82740.1 ureB2 Structure source: AlphaFold + ColabFold UniProt A0A422ZKQ5
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Amino acids 146
Annotations 4
Features 12
PDB binders 0
Druggability 0.103

Overview

Basic information about this protein and its source genome.

Accession
VK055_4195
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82740.1 ureB2
Status
annotated
Amino acids
146
Structure source
AlphaFold + ColabFold
EC
3.5.1.5
GO
GO:0043419 The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. GO:0035550 A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide). GO:0009039 Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
47.959
Localization
Cytoplasmic
ColabFold pLDDT
90.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.103
Structure A0A422ZKQ5
Pocket Pocket 1
P2Rank
Structure A0A422ZKQ5
Pocket No pockets
ColabFold model
FPocket 0.094 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 68 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0043419 The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2.
  • GO:0035550 A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).
  • GO:0009039 Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
12 122 PANTHER PTHR33569 UREASE
22 117 Pfam PF00699 Urease beta subunit
22 117 InterPro IPR002019 Urease, beta subunit-like
19 146 Gene3D G3DSA:2.10.150.10 Urease, beta subunit
19 146 InterPro IPR036461 Urease, beta subunit superfamily
22 123 SUPERFAMILY SSF51278 Urease, beta-subunit
22 123 InterPro IPR036461 Urease, beta subunit superfamily
19 119 Hamap MF_01954 Urease subunit beta [ureB].
19 119 InterPro IPR002019 Urease, beta subunit-like
22 119 NCBIfam TIGR00192 urease subunit beta
22 119 InterPro IPR002019 Urease, beta subunit-like
22 119 CDD cd00407 Urease_beta

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A422ZKQ5 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A422ZKQ5
AlphaFold — — full sequence — Viewing
ColabFold VK055_4195
ColabFold — — full sequence — Loaded