Protein profile

VK055_4205

crcB-like family protein

Genome: KpATCC43816

Gene: AIK82750.1 Structure source: AlphaFold + ColabFold UniProt A0A2L1BU99
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Amino acids 127
Annotations 5
Features 19
PDB binders 0
Druggability 0.501

Overview

Basic information about this protein and its source genome.

Accession
VK055_4205
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82750.1
Status
annotated
Amino acids
127
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0062054 Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel. GO:0046872 Binding to a metal ion. GO:0140114 Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include chemical modification or transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
33.684
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.501
Structure A0A2L1BU99
Pocket Pocket 2
P2Rank 0.298
Structure A0A2L1BU99
Pocket Pocket 1
ColabFold model
FPocket 0.585 · Pocket 4
P2Rank 0.345 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0062054 Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel.
  • GO:0046872 Binding to a metal ion.
  • GO:0140114 Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include chemical modification or transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
24 34 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
60 70 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
68 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 23 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 121 PANTHER PTHR28259 FLUORIDE EXPORT PROTEIN 1-RELATED
13 121 InterPro IPR003691 Putative fluoride ion transporter CrcB
126 127 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
102 124 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 89 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
90 100 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
101 125 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 126 Hamap MF_00454 Putative fluoride ion transporter CrcB [crcB].
6 126 InterPro IPR003691 Putative fluoride ion transporter CrcB
35 59 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 121 Pfam PF02537 CrcB-like protein, Camphor Resistance (CrcB)
8 121 InterPro IPR003691 Putative fluoride ion transporter CrcB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2L1BU99
AlphaFold — — full sequence — Viewing
ColabFold VK055_4205
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.124
4 0.006
3 0.0
8 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.91 0.298
2 2.69 0.065