Protein profile

VK055_4216

arsB

Genome: KpATCC43816

Gene: AIK82761.1 arsB Structure source: AlphaFold + ColabFold UniProt A0A0H3GSV2

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Amino acids 430

Annotations 7

Features 59

PDB binders 0

Druggability 0.896

Overview

Basic information about this protein and its source genome.

Accession: VK055_4216
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK82761.1 arsB
Status: annotated
Amino acids: 430
Structure source: AlphaFold + ColabFold

GO:0015700 The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015105 Enables the transfer of arsenite from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042960 Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0008490 Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 29.929
Localization: CytoplasmicMembrane
ColabFold pLDDT: 93.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.896

Structure A0A0H3GSV2

Pocket Pocket 8

P2Rank 0.428

Structure A0A0H3GSV2

Pocket Pocket 1

ColabFold model

FPocket 0.711 · Pocket 5

P2Rank 0.412 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 179 / 4744 genomes with a hit

Normalized 0.038

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

GO:0015700 The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0015105 Enables the transfer of arsenite from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0042960 Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
GO:0008490 Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
GO:0046685 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.

Sequence Features

Domain/signature hits from InterPro and related databases.

59 records

Show feature table

Start	End	DB	Term	Name
71	90	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
424	430	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
401	423	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
91	110	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
48	70	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
316	335	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
2	17	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
245	262	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
36	50	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3	426	NCBIfam	TIGR00935	arsenite/antimonite efflux transporter
3	426	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
178	198	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
224	241	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	43	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
229	422	PANTHER	PTHR43302	TRANSPORTER ARSB-RELATED
3	423	Pfam	PF02040	Arsenical pump membrane protein
3	423	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
222	240	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
111	115	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
101	125	PRINTS	PR00758	Arsenical pump membrane protein signature
101	125	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
144	168	PRINTS	PR00758	Arsenical pump membrane protein signature
144	168	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
177	200	PRINTS	PR00758	Arsenical pump membrane protein signature
177	200	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
364	389	PRINTS	PR00758	Arsenical pump membrane protein signature
364	389	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
323	345	PRINTS	PR00758	Arsenical pump membrane protein signature
323	345	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
397	421	PRINTS	PR00758	Arsenical pump membrane protein signature
397	421	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
278	302	PRINTS	PR00758	Arsenical pump membrane protein signature
278	302	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
217	242	PRINTS	PR00758	Arsenical pump membrane protein signature
217	242	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
297	315	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
114	131	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
3	412	CDD	cd01118	ArsB_permease
3	412	InterPro	IPR000802	Arsenical pump membrane protein, ArsB
138	160	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
274	296	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
264	274	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
199	221	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
175	197	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
173	177	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
18	35	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
246	263	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	35	Phobius	SIGNAL_PEPTIDE	Signal peptide region
335	400	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
275	296	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
141	151	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
91	110	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
116	140	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
316	334	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	1	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
241	245	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
51	70	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
152	172	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
401	423	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GSV2	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_4216	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
8				0.896
2				0.782
15				0.55
14				0.285

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	5.79	0.282
2	5.75	0.28
3	5.42	0.257
4	3.6	0.134
5	1.61	0.026

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.711
26				0.277
12				0.21

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	8.17	0.435
2	5.13	0.235
3	3.4	0.122
4	3.12	0.105
5	1.7	0.03