Protein profile

VK055_4235

phage integrase family protein

Genome: KpATCC43816

Gene: AIK82780.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GY09
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Amino acids 202
Annotations 3
Features 8
PDB binders 0
Druggability 0.345

Overview

Basic information about this protein and its source genome.

Accession
VK055_4235
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82780.1
Status
annotated
Amino acids
202
Structure source
AlphaFold + ColabFold
GO
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
53.552
DEG E-value
3.7399999999999994e-68
Localization
Cytoplasmic
ColabFold pLDDT
90.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.345
Structure A0A0H3GY09
Pocket Pocket 1
P2Rank 0.329
Structure A0A0H3GY09
Pocket Pocket 1
ColabFold model
FPocket 0.156 · Pocket 7
P2Rank 0.376 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 36 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 196 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
1 196 InterPro IPR013762 Integrase-like, catalytic domain superfamily
6 176 Pfam PF00589 Phage integrase family
6 176 InterPro IPR002104 Integrase, catalytic domain
2 184 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
2 184 InterPro IPR002104 Integrase, catalytic domain
3 184 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
3 184 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GY09
AlphaFold — — full sequence — Viewing
ColabFold VK055_4235
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.141
13 0.007
6 0.005
7 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.46 0.329