Protein profile

VK055_4331

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit

Genome: KpATCC43816

Gene: AIK82876.1 cbiT Structure source: AlphaFold + ColabFold UniProt A0A0H3GWZ3
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Amino acids 189
Annotations 4
Features 10
PDB binders 0
Druggability 0.386

Overview

Basic information about this protein and its source genome.

Accession
VK055_4331
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82876.1 cbiT
Status
annotated
Amino acids
189
Structure source
AlphaFold + ColabFold
GO
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
35.036
Localization
Cytoplasmic
ColabFold pLDDT
95.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.386
Structure A0A0H3GWZ3
Pocket Pocket 11
P2Rank 0.263
Structure A0A0H3GWZ3
Pocket Pocket 1
ColabFold model
FPocket 0.653 · Pocket 1
P2Rank 0.497 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 49 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein.
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
35 133 CDD cd02440 AdoMet_MTases
23 129 Pfam PF05175 Methyltransferase small domain
23 129 InterPro IPR007848 Methyltransferase small domain
3 156 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
3 156 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
2 185 PANTHER PTHR43182 COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING)
13 132 NCBIfam TIGR02469 precorrin-6Y C5,15-methyltransferase (decarboxylating) subunit CbiT
13 132 InterPro IPR014008 Cobalamin biosynthesis, precorrin-6Y methyltransferase, CbiT subunit
1 189 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
1 189 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWZ3
AlphaFold — — full sequence — Viewing
ColabFold VK055_4331
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.386
10 0.215
1 0.001
8 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.3 0.263
2 5.51 0.217