Protein profile

VK055_4339

cobalt transport family protein

Genome: KpATCC43816

Gene: cbiN AIK82884.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H273
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Amino acids 93
Annotations 5
Features 18
PDB binders 0
Druggability 0.352

Overview

Basic information about this protein and its source genome.

Accession
VK055_4339
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
cbiN AIK82884.1
Status
annotated
Amino acids
93
Structure source
AlphaFold + ColabFold
GO
GO:0006824 The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015087 Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.352
Structure A0A0H3H273
Pocket Pocket 1
P2Rank
Structure A0A0H3H273
Pocket No pockets
ColabFold model
FPocket 0.572 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006824 The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015087 Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other.
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
60 82 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
37 59 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 36 Phobius SIGNAL_PEPTIDE Signal peptide region
19 36 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
84 93 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 92 PANTHER PTHR38662 -
1 92 InterPro IPR003705 Cobalt transport protein CbiN
5 69 Pfam PF02553 Cobalt transport protein component CbiN
5 69 InterPro IPR003705 Cobalt transport protein CbiN
60 83 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 85 NCBIfam TIGR01165 cobalt ECF transporter S component CbiN
1 85 InterPro IPR003705 Cobalt transport protein CbiN
1 93 Hamap MF_00330 Cobalt transport protein CbiN [cbiN].
1 93 InterPro IPR003705 Cobalt transport protein CbiN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H273
AlphaFold — — full sequence — Viewing
ColabFold VK055_4339
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.352
5 0.233
2 0.0
3 0.0