Protein profile

VK055_4425

periplasmic binding family protein

Genome: KpATCC43816

Gene: AIK82968.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWS0
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Amino acids 265
Annotations 0
Features 9
PDB binders 0
Druggability 0.117

Overview

Basic information about this protein and its source genome.

Accession
VK055_4425
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82968.1
Status
annotated
Amino acids
265
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
27.068
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.02

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.117
Structure A0A0H3GWS0
Pocket Pocket 1
P2Rank 0.277
Structure A0A0H3GWS0
Pocket Pocket 1
ColabFold model
FPocket 0.267 · Pocket 10
P2Rank 0.449 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
12 242 CDD cd01149 HutB
12 258 SUPERFAMILY SSF53807 Helical backbone metal receptor
4 132 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
133 264 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
14 265 ProSiteProfiles PS50983 Iron siderophore/cobalamin periplasmic-binding domain profile.
14 265 InterPro IPR002491 ABC transporter periplasmic binding domain
10 257 PANTHER PTHR30535 VITAMIN B12-BINDING PROTEIN
16 240 Pfam PF01497 Periplasmic binding protein
16 240 InterPro IPR002491 ABC transporter periplasmic binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWS0
AlphaFold — — full sequence — Viewing
ColabFold VK055_4425
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.65 0.078