Protein profile

VK055_4480

lytic murein transglycosylase B

Genome: KpATCC43816

Gene: AIK83023.1 mltB Structure source: AlphaFold + ColabFold UniProt A0A0H3GS51
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Amino acids 329
Annotations 2
Features 12
PDB binders 1
Druggability 0.628

Overview

Basic information about this protein and its source genome.

Accession
VK055_4480
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83023.1 mltB
Status
annotated
Amino acids
329
Structure source
AlphaFold + ColabFold
GO
GO:0008933 Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. GO:0009253 The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
39.474
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.628
Structure A0A0H3GS51
Pocket Pocket 14
P2Rank 0.54
Structure A0A0H3GS51
Pocket Pocket 1
ColabFold model
FPocket 0.54 · Pocket 2
P2Rank 0.37 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 101 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008933 Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand.
  • GO:0009253 The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
15 324 SUPERFAMILY SSF53955 Lysozyme-like
15 324 InterPro IPR023346 Lysozyme-like domain superfamily
26 319 Pfam PF13406 Transglycosylase SLT domain
26 319 InterPro IPR031304 Transglycosylase SLT domain 2
68 319 Gene3D G3DSA:1.10.530.10 -
130 209 FunFam G3DSA:1.10.8.350:FF:000001 Lytic murein transglycosylase B
31 321 NCBIfam TIGR02282 lytic murein transglycosylase B
31 321 InterPro IPR011757 Lytic transglycosylase MltB
34 209 Gene3D G3DSA:1.10.8.350 Bacterial muramidase
12 326 PANTHER PTHR30163 MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE B
12 326 InterPro IPR043426 Membrane-bound lytic murein transglycosylase B-like
115 318 CDD cd13399 Slt35-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS51
AlphaFold — — full sequence — Viewing
ColabFold VK055_4480
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.628
3 0.016
7 0.007
16 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.76 0.54
2 1.84 0.029
3 1.55 0.019
4 1.34 0.013
5 1.25 0.01

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
BLG
1D0L
P41052 552.6 Da LogP -6.16 TPSA 271.9 3 viol. ✓ Clean CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O[C@H]2…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.