Protein profile

VK055_4532

type VII secretion system (T7SS), usher family protein

Genome: KpATCC43816

Gene: AIK83070.1 Structure source: AlphaFold + ColabFold UniProt A0A483GDK2
Export view
Amino acids 820
Annotations 5
Features 21
PDB binders 0
Druggability 0.813

Overview

Basic information about this protein and its source genome.

Accession
VK055_4532
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83070.1
Status
annotated
Amino acids
820
Structure source
AlphaFold + ColabFold
GO
GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515 Binding to a protein. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
36.715
Localization
OuterMembrane
ColabFold pLDDT
86.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.813
Structure A0A483GDK2
Pocket Pocket 3
P2Rank 0.433
Structure A0A483GDK2
Pocket Pocket 1
ColabFold model
FPocket 0.869 · Pocket 59
P2Rank 0.391 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 19 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005515 Binding to a protein.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
288 298 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
288 298 InterPro IPR018030 Fimbrial membrane usher, conserved site
246 335 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
637 727 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
637 727 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
637 727 FunFam G3DSA:2.60.40.2610:FF:000001 Outer membrane fimbrial usher protein
15 160 Pfam PF13954 PapC N-terminal domain
15 160 InterPro IPR025885 PapC, N-terminal domain
177 721 Pfam PF00577 Outer membrane usher protein
177 721 InterPro IPR000015 Outer membrane usher protein
5 809 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
5 809 InterPro IPR000015 Outer membrane usher protein
32 149 Gene3D G3DSA:3.10.20.410 -
32 149 InterPro IPR037224 PapC, N-terminal domain superfamily
40 152 SUPERFAMILY SSF141729 FimD N-terminal domain-like
40 152 InterPro IPR037224 PapC, N-terminal domain superfamily
246 335 Gene3D G3DSA:2.60.40.3110 -
728 819 Gene3D G3DSA:2.60.40.2070 -
728 819 InterPro IPR043142 PapC-like, C-terminal domain superfamily
731 800 Pfam PF13953 PapC C-terminal domain
731 800 InterPro IPR025949 PapC-like, C-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483GDK2
AlphaFold — — full sequence — Viewing
ColabFold VK055_4532
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.813
66 0.642
1 0.429
57 0.273

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.81 0.349
2 1.56 0.024