Protein profile

VK055_4538

bacterial regulatory, luxR family protein

Genome: KpATCC43816

Gene: AIK83076.1 Structure source: AlphaFold + ColabFold UniProt A0A0C7K6Y4
Export view
Amino acids 233
Annotations 2
Features 20
PDB binders 0
Druggability 0.972

Overview

Basic information about this protein and its source genome.

Accession
VK055_4538
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83076.1
Status
annotated
Amino acids
233
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
80.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.972
Structure A0A0C7K6Y4
Pocket Pocket 1
P2Rank 0.255
Structure A0A0C7K6Y4
Pocket Pocket 1
ColabFold model
FPocket 0.341 · Pocket 19
P2Rank 0.176 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
136 231 Gene3D G3DSA:1.10.10.10 -
136 231 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
48 233 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
170 227 SMART SM00421 luxrmega5
170 227 InterPro IPR000792 Transcription regulator LuxR, C-terminal
27 47 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 15 SignalP_EUK SignalP-TM SignalP-TM
173 229 CDD cd06170 LuxR_C_like
173 229 InterPro IPR000792 Transcription regulator LuxR, C-terminal
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region
169 229 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
169 229 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
166 231 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
166 231 InterPro IPR000792 Transcription regulator LuxR, C-terminal
18 26 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
173 226 Pfam PF00196 Bacterial regulatory proteins, luxR family
173 226 InterPro IPR000792 Transcription regulator LuxR, C-terminal
13 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7K6Y4
AlphaFold — — full sequence — Viewing
ColabFold VK055_4538
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.972

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.84 0.036