Protein profile

VK055_4552

efflux transporter, RND family, MFP subunit

Genome: KpATCC43816

Gene: AIK83090.1 Structure source: AlphaFold + ColabFold UniProt A0A1Y0PW27
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Amino acids 391
Annotations 5
Features 20
PDB binders 0
Druggability 0.45

Overview

Basic information about this protein and its source genome.

Accession
VK055_4552
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83090.1
Status
annotated
Amino acids
391
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
33.431
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.45
Structure A0A1Y0PW27
Pocket Pocket 9
P2Rank 0.409
Structure A0A1Y0PW27
Pocket Pocket 1
ColabFold model
FPocket 0.727 · Pocket 1
P2Rank 0.335 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 44 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
60 287 Gene3D G3DSA:2.40.30.170 -
67 297 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
67 297 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
1 27 SignalP_EUK SignalP-noTM SignalP-noTM
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
66 211 Gene3D G3DSA:2.40.50.100 -
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
28 391 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
10 387 PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
24 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
288 380 FunFam G3DSA:2.40.420.20:FF:000001 Efflux RND transporter periplasmic adaptor subunit
42 378 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
42 378 InterPro IPR006143 RND efflux pump, membrane fusion protein
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
288 380 Gene3D G3DSA:2.40.420.20 -
152 172 Coils Coil Coil
57 302 SUPERFAMILY SSF111369 HlyD-like secretion proteins
107 127 Coils Coil Coil
1 27 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
101 174 Gene3D G3DSA:1.10.287.470 Helix hairpin bin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1Y0PW27
AlphaFold — — full sequence — Viewing
ColabFold VK055_4552
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
25 0.028
3 0.02
1 0.018
13 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.91 0.409