Protein profile

VK055_4628

TPR repeat family protein

Genome: KpATCC43816

Gene: AIK83162.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW73
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Amino acids 1065
Annotations 2
Features 29
PDB binders 0
Druggability 0.736

Overview

Basic information about this protein and its source genome.

Accession
VK055_4628
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83162.1
Status
annotated
Amino acids
1065
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.736
Structure A0A0H3GW73
Pocket Pocket 12
P2Rank 0.983
Structure A0A0H3GW73
Pocket Pocket 1
ColabFold model
FPocket 0.495 · Pocket 66
P2Rank 0.983 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 27 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005515 Binding to a protein.
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
865 1060 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
865 1060 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
14 318 Pfam PF17128 Domain of unknown function (DUF5107)
14 318 InterPro IPR033396 Domain of unknown function DUF5107
722 1048 PANTHER PTHR12558 CELL DIVISION CYCLE 16,23,27
716 983 SUPERFAMILY SSF48452 TPR-like
716 983 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
419 635 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
419 635 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
542 575 SMART SM00028 tpr_5
542 575 InterPro IPR019734 Tetratricopeptide repeat
953 986 SMART SM00028 tpr_5
953 986 InterPro IPR019734 Tetratricopeptide repeat
576 609 SMART SM00028 tpr_5
576 609 InterPro IPR019734 Tetratricopeptide repeat
752 786 SMART SM00028 tpr_5
752 786 InterPro IPR019734 Tetratricopeptide repeat
909 942 SMART SM00028 tpr_5
909 942 InterPro IPR019734 Tetratricopeptide repeat
718 751 SMART SM00028 tpr_5
718 751 InterPro IPR019734 Tetratricopeptide repeat
648 802 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
648 802 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
718 751 ProSiteProfiles PS50005 TPR repeat profile.
456 601 SUPERFAMILY SSF48452 TPR-like
456 601 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
548 607 Pfam PF13432 Tetratricopeptide repeat
731 786 Pfam PF13432 Tetratricopeptide repeat
872 937 Pfam PF13432 Tetratricopeptide repeat

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW73
AlphaFold — — full sequence — Viewing
ColabFold VK055_4628
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.736
1 0.413
22 0.302
42 0.274

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 31.53 0.939
2 18.4 0.822
3 16.83 0.788
4 8.75 0.468
5 7.42 0.389