Protein profile

VK055_4654

putative membrane protein

Genome: KpATCC43816

Gene: AIK83188.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWN6
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Amino acids 331
Annotations 4
Features 22
PDB binders 0
Druggability 0.457

Overview

Basic information about this protein and its source genome.

Accession
VK055_4654
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83188.1
Status
annotated
Amino acids
331
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008360 Any process that modulates the surface configuration of a cell. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
77.419
DEG E-value
2.23e-178
Localization
Unknown
ColabFold pLDDT
70.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.457
Structure A0A0H3GWN6
Pocket Pocket 1
P2Rank
Structure A0A0H3GWN6
Pocket No pockets
ColabFold model
FPocket 0.453 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 93 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0008360 Any process that modulates the surface configuration of a cell.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
4 110 Gene3D G3DSA:1.10.260.40 -
4 110 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
1 21 MobiDBLite mobidb-lite consensus disorder prediction
3 325 PANTHER PTHR34475 -
1 111 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
249 323 Pfam PF13464 Domain of unknown function (DUF4115)
249 323 InterPro IPR025194 Domain of unknown function DUF4115
18 79 SMART SM00530 mbf_short4
18 79 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
112 133 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 80 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
14 80 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
18 79 Pfam PF13413 Helix-turn-helix domain
16 79 CDD cd00093 HTH_XRE
16 79 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
1 326 Hamap MF_02017 Cytoskeleton protein RodZ [rodZ].
1 326 InterPro IPR023690 Cytoskeleton protein RodZ
134 331 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
111 133 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
144 241 MobiDBLite mobidb-lite consensus disorder prediction
19 48 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
19 48 InterPro IPR001387 Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWN6
AlphaFold — — full sequence — Viewing
ColabFold VK055_4654
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.021
4 0.0
10 0.0
21 0.0