Protein profile

VK055_4667

phage integrase family protein

Genome: KpATCC43816

Gene: AIK83201.1 Structure source: ColabFold
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Amino acids 396
Annotations 3
Features 16
PDB binders 0
Druggability 0.561

Overview

Basic information about this protein and its source genome.

Accession
VK055_4667
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83201.1
Status
annotated
Amino acids
396
Structure source
ColabFold
GO
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.49

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.561
Structure CB_VK055_4667
Pocket Pocket 4
P2Rank 0.364
Structure CB_VK055_4667
Pocket Pocket 1
ColabFold model
FPocket 0.561 · Pocket 4
P2Rank 0.364 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 32 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
98 384 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
98 384 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
1 100 Gene3D G3DSA:3.30.160.390 -
1 100 InterPro IPR038488 Integrase, DNA-binding domain superfamily
101 195 Gene3D G3DSA:1.10.150.130 -
101 195 InterPro IPR010998 Integrase/recombinase, N-terminal
204 373 Pfam PF00589 Phage integrase family
204 373 InterPro IPR002104 Integrase, catalytic domain
199 383 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
199 383 InterPro IPR002104 Integrase, catalytic domain
2 395 PANTHER PTHR30629 PROPHAGE INTEGRASE
205 390 CDD cd00801 INT_P4_C
198 389 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
198 389 InterPro IPR013762 Integrase-like, catalytic domain superfamily
2 88 Pfam PF13356 Arm DNA-binding domain
2 88 InterPro IPR025166 Integrase, DNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_4667
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.561
1 0.118
5 0.104
2 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.08 0.364
2 3.63 0.109