Protein profile

VK055_4698

gcvR GcvR predicted transcriptional regulator

Genome: KpATCC43816

Gene: AIK83232.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTH7
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Amino acids 188
Annotations 2
Features 14
PDB binders 0
Druggability 0.473

Overview

Basic information about this protein and its source genome.

Accession
VK055_4698
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83232.1
Status
annotated
Amino acids
188
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.185
DEG E-value
8.470000000000001e-117
Localization
Cytoplasmic
ColabFold pLDDT
88.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.473
Structure A0A0H3GTH7
Pocket Pocket 2
P2Rank 0.019
Structure A0A0H3GTH7
Pocket Pocket 1
ColabFold model
FPocket 0.339 · Pocket 4
P2Rank 0.009 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 110 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
6 86 SUPERFAMILY SSF55021 ACT-like
6 86 InterPro IPR045865 ACT-like domain
91 187 Gene3D G3DSA:3.30.70.260 -
5 179 PIRSF PIRSF028103 GcvR
5 179 InterPro IPR016867 Glycine cleavage system transcriptional repressor
7 82 Pfam PF13740 ACT domain
1 184 PANTHER PTHR34875 UPF0237 PROTEIN MJ1558
8 84 CDD cd04893 ACT_GcvR_1
4 88 FunFam G3DSA:3.30.70.260:FF:000005 Glycine cleavage system transcriptional repressor
91 178 SUPERFAMILY SSF55021 ACT-like
91 178 InterPro IPR045865 ACT-like domain
3 88 Gene3D G3DSA:3.30.70.260 -
97 175 ProSiteProfiles PS51671 ACT domain profile.
97 175 InterPro IPR002912 ACT domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTH7
AlphaFold — — full sequence — Viewing
ColabFold VK055_4698
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.01
4 0.003
8 0.002
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.55 0.019