Protein profile

VK055_4717

cupin domain protein

Genome: KpATCC43816

Gene: AIK83251.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW00
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Amino acids 229
Annotations 0
Features 9
PDB binders 0
Druggability 0.447

Overview

Basic information about this protein and its source genome.

Accession
VK055_4717
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83251.1
Status
annotated
Amino acids
229
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.57

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.447
Structure A0A0H3GW00
Pocket Pocket 1
P2Rank 0.365
Structure A0A0H3GW00
Pocket Pocket 1
ColabFold model
FPocket 0.466 · Pocket 2
P2Rank 0.217 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 33 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
81 228 Pfam PF06249 Ethanolamine utilisation protein EutQ
81 228 InterPro IPR010424 Acetate kinase EutQ
105 226 SUPERFAMILY SSF51182 RmlC-like cupins
105 226 InterPro IPR011051 RmlC-like cupin domain superfamily
97 229 Gene3D G3DSA:2.60.120.10 Jelly Rolls
97 229 InterPro IPR014710 RmlC-like jelly roll fold
27 228 PANTHER PTHR36169 ETHANOLAMINE UTILIZATION PROTEIN EUTQ
27 228 InterPro IPR010424 Acetate kinase EutQ
139 222 CDD cd02228 cupin_EutQ

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW00
AlphaFold — — full sequence — Viewing
ColabFold VK055_4717
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.196
3 0.028
2 0.003
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.1 0.365
2 1.35 0.013
3 0.83 0.002