Protein profile

VK055_4774

glucokinase

Genome: KpATCC43816

Gene: AIK83302.1 glk Structure source: ColabFold
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Amino acids 278
Annotations 5
Features 11
PDB binders 0
Druggability 0.655

Overview

Basic information about this protein and its source genome.

Accession
VK055_4774
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83302.1 glk
Status
annotated
Amino acids
278
Structure source
ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051156 The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. GO:0005536 Binding to D-enantiomers of glucose. GO:0004340 Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. GO:0006096 The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.93

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.655
Structure CB_VK055_4774
Pocket Pocket 8
P2Rank 0.732
Structure CB_VK055_4774
Pocket Pocket 1
ColabFold model
FPocket 0.655 · Pocket 8
P2Rank 0.732 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 116 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0051156 The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.
  • GO:0005536 Binding to D-enantiomers of glucose.
  • GO:0004340 Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
  • GO:0006096 The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
2 265 Gene3D G3DSA:3.30.420.40 -
57 256 FunFam G3DSA:3.40.367.20:FF:000002 Glucokinase
57 256 Gene3D G3DSA:3.40.367.20 -
201 223 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 272 Pfam PF02685 Glucokinase
1 272 InterPro IPR003836 Glucokinase
1 267 NCBIfam TIGR00749 glucokinase
1 267 InterPro IPR003836 Glucokinase
2 276 PANTHER PTHR47690 GLUCOKINASE
2 275 SUPERFAMILY SSF53067 Actin-like ATPase domain
2 275 InterPro IPR043129 ATPase, nucleotide binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_4774
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.655
14 0.101
2 0.014
1 0.005

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.62 0.732
2 1.97 0.035
3 1.59 0.02
4 1.5 0.018
5 1.15 0.008