Protein profile

VK055_4791

phosphohistidine phosphatase SixA

Genome: KpATCC43816

Gene: AIK83318.1 sixA Structure source: AlphaFold + ColabFold UniProt A0A0H3H150
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Amino acids 128
Annotations 3
Features 8
PDB binders 0
Druggability 0.048

Overview

Basic information about this protein and its source genome.

Accession
VK055_4791
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83318.1 sixA
Status
annotated
Amino acids
128
Structure source
AlphaFold + ColabFold
GO
GO:0101006 Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0036211 The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.594
DEG E-value
2.08e-77
Localization
Unknown
ColabFold pLDDT
94.44

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.048
Structure A0A0H3H150
Pocket Pocket 5
P2Rank 0.906
Structure A0A0H3H150
Pocket Pocket 1
ColabFold model
FPocket 0.106 · Pocket 6
P2Rank 0.811 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 106 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0101006 Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0036211 The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 119 NCBIfam TIGR00249 phosphohistidine phosphatase SixA
1 119 InterPro IPR004449 Phosphohistidine phosphatase SixA
2 112 SUPERFAMILY SSF53254 Phosphoglycerate mutase-like
2 112 InterPro IPR029033 Histidine phosphatase superfamily
1 115 CDD cd07067 HP_PGM_like
1 115 InterPro IPR013078 Histidine phosphatase superfamily, clade-1
1 128 Gene3D G3DSA:3.40.50.1240 -
1 128 InterPro IPR029033 Histidine phosphatase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H150
AlphaFold — — full sequence — Viewing
ColabFold VK055_4791
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.63 0.657
2 3.82 0.148
3 2.54 0.071
4 1.92 0.039