Protein profile

VK055_4809

cell division protein DedD

Genome: KpATCC43816

Gene: AIK83336.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWD7
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Amino acids 216
Annotations 5
Features 19
PDB binders 0
Druggability 0.012

Overview

Basic information about this protein and its source genome.

Accession
VK055_4809
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83336.1
Status
annotated
Amino acids
216
Structure source
AlphaFold + ColabFold
GO
GO:0032506 A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
66.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.012
Structure A0A0H3GWD7
Pocket Pocket 7
P2Rank
Structure A0A0H3GWD7
Pocket No pockets
ColabFold model
FPocket 0.143 · Pocket 2
P2Rank 0.028 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 85 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0032506 A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).
  • GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
  • GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
  • GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
1 215 Hamap MF_02022 Cell division protein DedD [dedD].
1 215 InterPro IPR032898 Cell division protein DedD
134 213 ProSiteProfiles PS51724 SPOR domain profile.
134 213 InterPro IPR007730 Sporulation-like domain
1 16 SignalP_EUK SignalP-noTM SignalP-noTM
136 211 Gene3D G3DSA:3.30.70.1070 Sporulation related repeat
136 211 InterPro IPR036680 Sporulation-like domain superfamily
139 211 FunFam G3DSA:3.30.70.1070:FF:000001 Cell division protein DedD
2 213 PANTHER PTHR38687 CELL DIVISION PROTEIN DEDD-RELATED
11 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
137 210 Pfam PF05036 SPOR domain
137 210 InterPro IPR007730 Sporulation-like domain
17 216 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
136 211 SUPERFAMILY SSF110997 Sporulation related repeat
2 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
29 138 MobiDBLite mobidb-lite consensus disorder prediction
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region
95 122 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWD7
AlphaFold — — full sequence — Viewing
ColabFold VK055_4809
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer