Protein profile

VK055_4879

acetyl-CoA:acetoacetyl-CoA transferase, beta subunit

Genome: KpATCC43816

Gene: AIK83406.1 atoA Structure source: AlphaFold + ColabFold UniProt A0A2X3IKJ5
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Amino acids 216
Annotations 3
Features 14
PDB binders 0
Druggability 0.391

Overview

Basic information about this protein and its source genome.

Accession
VK055_4879
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83406.1 atoA
Status
annotated
Amino acids
216
Structure source
AlphaFold + ColabFold
EC
2.8.3.8
GO
GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). GO:0008775 Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
46.512
Human E-value
1.07e-61
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
68.72
DEG E-value
1.66e-104
Localization
Cytoplasmic
ColabFold pLDDT
95.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.391
Structure A0A2X3IKJ5
Pocket Pocket 10
P2Rank 0.706
Structure A0A2X3IKJ5
Pocket Pocket 1
ColabFold model
FPocket 0.83 · Pocket 4
P2Rank 0.717 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 312 / 4744 genomes with a hit
Normalized 0.066

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
  • GO:0008775 Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
2 208 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
2 208 InterPro IPR037171 NagB/RpiA transferase-like
1 215 Gene3D G3DSA:3.40.1080.10 -
1 210 FunFam G3DSA:3.40.1080.10:FF:000001 Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b
3 209 PANTHER PTHR13707 KETOACID-COENZYME A TRANSFERASE
3 209 InterPro IPR004165 Coenzyme A transferase family I
5 198 SMART SM00882 CoA_trans_3
5 198 InterPro IPR004165 Coenzyme A transferase family I
43 51 ProSitePatterns PS01274 Coenzyme A transferases signature 2.
43 51 InterPro IPR004164 Coenzyme A transferase active site
5 183 Pfam PF01144 Coenzyme A transferase
5 183 InterPro IPR004165 Coenzyme A transferase family I
3 204 NCBIfam TIGR02428 3-oxoacid CoA-transferase subunit B
3 204 InterPro IPR012791 3-oxoacid CoA-transferase, subunit B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2X3IKJ5
AlphaFold — — full sequence — Viewing
ColabFold VK055_4879
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.391
2 0.029
1 0.001
9 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.64 0.706