Protein profile

VK055_4893

ecotin family protein

Genome: KpATCC43816

Gene: AIK83420.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW64
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Amino acids 163
Annotations 2
Features 26
PDB binders 0
Druggability 0.241

Overview

Basic information about this protein and its source genome.

Accession
VK055_4893
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83420.1
Status
annotated
Amino acids
163
Structure source
AlphaFold + ColabFold
GO
GO:0004867 Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
88.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.241
Structure A0A0H3GW64
Pocket Pocket 1
P2Rank
Structure A0A0H3GW64
Pocket No pockets
ColabFold model
FPocket 0.331 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004867 Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 105 FunFam G3DSA:2.60.40.550:FF:000001 Ecotin
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 163 PIRSF PIRSF006865 Ecotin
1 163 InterPro IPR005658 Proteinase inhibitor I11, ecotin
4 163 Hamap MF_00706 Ecotin [eco].
4 163 InterPro IPR023084 Proteinase inhibitor I11, ecotin, gammaproteobacteria
31 153 Pfam PF03974 Ecotin
31 153 InterPro IPR005658 Proteinase inhibitor I11, ecotin
106 163 Gene3D G3DSA:4.10.1230.10 Ecotin, trypsin inhibitor
106 163 InterPro IPR027438 Ecotin, C-terminal
16 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
24 163 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 16 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
106 163 FunFam G3DSA:4.10.1230.10:FF:000001 Ecotin
26 162 CDD cd00242 Ecotin
26 162 InterPro IPR023084 Proteinase inhibitor I11, ecotin, gammaproteobacteria
23 105 Gene3D G3DSA:2.60.40.550 Ecotin
26 161 PANTHER PTHR35890 -
26 161 InterPro IPR005658 Proteinase inhibitor I11, ecotin
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 161 SUPERFAMILY SSF49772 Ecotin, trypsin inhibitor
27 161 InterPro IPR036198 Ecotin superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW64
AlphaFold — — full sequence — Viewing
ColabFold VK055_4893
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.241