Protein profile

VK055_4938

hypothetical protein

Genome: KpATCC43816

Gene: AIK83464.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW34
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Amino acids 238
Annotations 1
Features 13
PDB binders 0
Druggability 0.64

Overview

Basic information about this protein and its source genome.

Accession
VK055_4938
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83464.1
Status
annotated
Amino acids
238
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
92.437
DEG E-value
4.25e-153
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.64
Structure A0A0H3GW34
Pocket Pocket 12
P2Rank 0.513
Structure A0A0H3GW34
Pocket Pocket 1
ColabFold model
FPocket 0.683 · Pocket 6
P2Rank 0.484 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
6 179 PANTHER PTHR30336 INNER MEMBRANE PROTEIN, PROBABLE PERMEASE
1 238 PIRSF PIRSF005011 SanA
1 238 InterPro IPR023604 Uncharacterised protein family SanA
48 183 Pfam PF02698 DUF218 domain
48 183 InterPro IPR003848 Domain of unknown function DUF218
23 238 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
46 186 CDD cd06259 YdcF-like
46 186 InterPro IPR003848 Domain of unknown function DUF218
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
8 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW34
AlphaFold — — full sequence — Viewing
ColabFold VK055_4938
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.64
2 0.491
5 0.0
16 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.11 0.513
2 2.12 0.04
3 2.08 0.039