Protein profile

VK055_4959

putative uPF0387 membrane protein yohO

Genome: KpATCC43816

Gene: AIK83485.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQV2
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Amino acids 37
Annotations 1
Features 8
PDB binders 0
Druggability 0.392

Overview

Basic information about this protein and its source genome.

Accession
VK055_4959
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83485.1
Status
annotated
Amino acids
37
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
77.143
DEG E-value
4.53e-12
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.392
Structure A0A0H3GQV2
Pocket Pocket 1
P2Rank
Structure A0A0H3GQV2
Pocket No pockets
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
26 37 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
10 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 34 Hamap MF_01362 UPF0387 membrane protein YohO [yohO].
1 34 InterPro IPR020870 Uncharacterised protein family UPF0387, membrane
18 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQV2
AlphaFold — — full sequence — Viewing
ColabFold VK055_4959
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.392