Protein profile

VK055_4982

helix-turn-helix domain protein

Genome: KpATCC43816

Gene: AIK83508.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVC1
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Amino acids 313
Annotations 2
Features 9
PDB binders 0
Druggability 0.466

Overview

Basic information about this protein and its source genome.

Accession
VK055_4982
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83508.1
Status
annotated
Amino acids
313
Structure source
AlphaFold + ColabFold
GO
GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
27.864
Localization
Cytoplasmic
ColabFold pLDDT
94.35

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.466
Structure A0A0H3GVC1
Pocket Pocket 13
P2Rank 0.937
Structure A0A0H3GVC1
Pocket Pocket 1
ColabFold model
FPocket 0.76 · Pocket 8
P2Rank 0.913 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 18 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
54 311 Gene3D G3DSA:3.40.50.1360 -
3 312 PANTHER PTHR34294 TRANSCRIPTIONAL REGULATOR-RELATED
1 53 Gene3D G3DSA:1.10.10.10 -
1 53 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
59 311 Pfam PF04198 Putative sugar-binding domain
59 311 InterPro IPR007324 Sugar-binding domain, putative
8 52 Pfam PF13384 Homeodomain-like domain
59 311 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
59 311 InterPro IPR037171 NagB/RpiA transferase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVC1
AlphaFold — — full sequence — Viewing
ColabFold VK055_4982
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.466
1 0.2
4 0.122
19 0.014

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 36.77 0.937
2 3.03 0.08
3 1.81 0.028
4 1.73 0.025