Protein profile

VK055_4989

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK83515.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQS3
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Amino acids 345
Annotations 4
Features 32
PDB binders 0
Druggability 0.849

Overview

Basic information about this protein and its source genome.

Accession
VK055_4989
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83515.1
Status
annotated
Amino acids
345
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
32.727
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.18

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.849
Structure A0A0H3GQS3
Pocket Pocket 15
P2Rank 0.55
Structure A0A0H3GQS3
Pocket Pocket 1
ColabFold model
FPocket 0.704 · Pocket 23
P2Rank 0.542 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
123 344 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
123 344 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
309 331 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 344 PANTHER PTHR43163 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
105 326 CDD cd06261 TM_PBP2
105 326 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
205 227 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
229 266 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
111 132 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
105 336 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
105 336 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
313 336 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 108 Pfam PF19300 Binding-prot-dependent transport system membrane comp, N-term
15 108 InterPro IPR045621 ABC transporter type 1, GsiC-like, N-terminal domain
1 18 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
170 204 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
337 345 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
294 312 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
133 143 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
267 293 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
205 228 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
153 175 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
38 110 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
19 37 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
110 132 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
101 330 SUPERFAMILY SSF161098 MetI-like
101 330 InterPro IPR035906 MetI-like superfamily
267 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
144 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
96 345 Gene3D G3DSA:1.10.3720.10 -
96 345 InterPro IPR035906 MetI-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQS3
AlphaFold — — full sequence — Viewing
ColabFold VK055_4989
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.849
26 0.643
6 0.347
27 0.251

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.97 0.423
2 2.67 0.079
3 1.96 0.041
4 1.6 0.025
5 0.91 0.004