Protein profile

VK055_4990

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK83516.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0N8
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Amino acids 301
Annotations 3
Features 31
PDB binders 0
Druggability 0.87

Overview

Basic information about this protein and its source genome.

Accession
VK055_4990
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83516.1
Status
annotated
Amino acids
301
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.939
DEG E-value
9.82e-77
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.78

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87
Structure A0A0H3H0N8
Pocket Pocket 2
P2Rank 0.541
Structure A0A0H3H0N8
Pocket Pocket 1
ColabFold model
FPocket 0.946 · Pocket 5
P2Rank 0.541 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
124 134 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
101 280 CDD cd06261 TM_PBP2
101 280 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
141 163 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
229 248 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
290 301 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
118 299 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
118 299 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
268 289 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
104 289 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
104 289 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
32 300 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
1 38 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
135 159 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 123 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
160 164 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
36 72 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
36 72 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain
165 182 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
183 228 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
249 267 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
91 296 Gene3D G3DSA:1.10.3720.10 -
91 296 InterPro IPR035906 MetI-like superfamily
267 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 282 SUPERFAMILY SSF161098 MetI-like
95 282 InterPro IPR035906 MetI-like superfamily
62 101 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
230 247 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0N8
AlphaFold — — full sequence — Viewing
ColabFold VK055_4990
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.87
19 0.613

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.21 0.549
2 2.75 0.084
3 1.91 0.039
4 1.34 0.015
5 1.19 0.01