Protein profile

VK055_5025

undecaprenyl-phosphate glucose phosphotransferase

Genome: KpATCC43816

Gene: AIK83551.1 wcaJ Structure source: AlphaFold + ColabFold UniProt A0A193SCR0
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Amino acids 465
Annotations 3
Features 25
PDB binders 0
Druggability 0.898

Overview

Basic information about this protein and its source genome.

Accession
VK055_5025
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83551.1 wcaJ
Status
annotated
Amino acids
465
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0089702 Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP. GO:0009242 The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
44.776
Localization
CytoplasmicMembrane
ColabFold pLDDT
82.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.898
Structure A0A193SCR0
Pocket Pocket 15
P2Rank 0.731
Structure A0A193SCR0
Pocket Pocket 1
ColabFold model
FPocket 0.928 · Pocket 11
P2Rank 0.843 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 59 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0089702 Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP.
  • GO:0009242 The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
50 69 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
138 279 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
81 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
144 465 PANTHER PTHR30576 COLANIC BIOSYNTHESIS UDP-GLUCOSE LIPID CARRIER TRANSFERASE
275 457 Pfam PF02397 Bacterial sugar transferase
275 457 InterPro IPR003362 Bacterial sugar transferase
113 135 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
81 103 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
70 80 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
24 465 NCBIfam TIGR03023 undecaprenyl-phosphate glucose phosphotransferase
24 465 InterPro IPR017473 Undecaprenyl-phosphate glucose phosphotransferase, WcaJ
113 137 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
45 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 25 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
102 112 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
280 301 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 465 NCBIfam TIGR03025 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
24 465 InterPro IPR017475 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase
302 465 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
142 263 Gene3D G3DSA:3.40.50.720 -
280 301 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
65 239 Pfam PF13727 CoA-binding domain
47 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A193SCR0
AlphaFold — — full sequence — Viewing
ColabFold VK055_5025
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.898
21 0.23

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.91 0.739
2 11.7 0.622
3 2.64 0.077
4 2.21 0.054
5 2.14 0.05