Protein profile

VK055_5075

winged helix-turn-helix DNA-binding family protein

Genome: KpATCC43816

Gene: AIK83601.1 Structure source: AlphaFold + ColabFold UniProt A4GZH8
Export view
Amino acids 182
Annotations 0
Features 8
PDB binders 0
Druggability 0.416

Overview

Basic information about this protein and its source genome.

Accession
VK055_5075
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83601.1
Status
annotated
Amino acids
182
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.416
Structure A4GZH8
Pocket Pocket 1
P2Rank
Structure A4GZH8
Pocket No pockets
ColabFold model
FPocket 0.336 · Pocket 10
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
118 159 Pfam PF13412 Winged helix-turn-helix DNA-binding
118 166 Gene3D G3DSA:1.10.10.10 -
118 166 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
120 165 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
120 165 InterPro IPR036390 Winged helix DNA-binding domain superfamily
136 156 Coils Coil Coil
131 157 ProSitePatterns PS00519 AsnC-type HTH domain signature.
131 157 InterPro IPR019885 Transcription regulator HTH, AsnC-type, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A4GZH8
AlphaFold — — full sequence — Viewing
ColabFold VK055_5075
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.416
2 0.028
6 0.013
10 0.002