Protein profile

VK055_5109

antidote-toxin recognition MazE family protein

Genome: KpATCC43816

Gene: AIK83635.1 Structure source: AlphaFold + ColabFold UniProt A4GZE4
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Amino acids 76
Annotations 1
Features 11
PDB binders 0
Druggability 0.291

Overview

Basic information about this protein and its source genome.

Accession
VK055_5109
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83635.1
Status
annotated
Amino acids
76
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
37.5
Localization
Unknown
ColabFold pLDDT
89.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.291
Structure A4GZE4
Pocket Pocket 3
P2Rank
Structure A4GZE4
Pocket No pockets
ColabFold model
FPocket 0.236 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 32 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
7 47 Pfam PF04014 Antidote-toxin recognition MazE, bacterial antitoxin
7 47 InterPro IPR007159 SpoVT-AbrB domain
4 45 ProSiteProfiles PS51740 SpoVT-AbrB domain profile.
4 45 InterPro IPR007159 SpoVT-AbrB domain
7 48 SMART SM00966 SpoVT_AbrB_2_a
7 48 InterPro IPR007159 SpoVT-AbrB domain
3 68 SUPERFAMILY SSF89447 AbrB/MazE/MraZ-like
3 68 InterPro IPR037914 SpoVT-AbrB domain superfamily
2 70 PANTHER PTHR37550 ANTITOXIN VAPB1
5 42 Gene3D G3DSA:2.10.260.10 -
4 74 NCBIfam NF040493 type II toxin-antitoxin system VapB family antitoxin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A4GZE4
AlphaFold — — full sequence — Viewing
ColabFold VK055_5109
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.291
5 0.005
1 0.004
2 0.002