Protein profile

VK055_5171

phage Terminase family protein

Genome: KpATCC43816

Gene: AIK83692.1 Structure source: AlphaFold + ColabFold UniProt A0A9Q6EYF1
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Amino acids 510
Annotations 1
Features 8
PDB binders 0
Druggability 0.893

Overview

Basic information about this protein and its source genome.

Accession
VK055_5171
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83692.1
Status
annotated
Amino acids
510
Structure source
AlphaFold + ColabFold
GO
GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.893
Structure A0A9Q6EYF1
Pocket Pocket 9
P2Rank 0.427
Structure A0A9Q6EYF1
Pocket Pocket 1
ColabFold model
FPocket 0.66 · Pocket 11
P2Rank 0.563 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
236 489 Pfam PF20441 Terminase large subunit, endonuclease domain
236 489 InterPro IPR046462 Terminase large subunit-like, endonuclease domain
53 194 Pfam PF03354 Terminase large subunit, ATPase domain
53 194 InterPro IPR046461 Terminase large subunit-like, ATPase domain
2 207 Gene3D G3DSA:3.40.50.300 -
2 207 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
7 498 PANTHER PTHR41287 -
7 498 InterPro IPR005021 Terminase large subunit-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A9Q6EYF1
AlphaFold — — full sequence — Viewing
ColabFold VK055_5171
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.893
18 0.25

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.27 0.44
2 1.89 0.038
3 1.78 0.033
4 0.91 0.004