Protein profile

KP13_05048

L-tartrate/succinate antiporter

Genome: KpKP13

Gene: ttdT AHE44778.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSE8
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Amino acids 503
Annotations 3
Features 49
PDB binders 3
Druggability 0.807

Overview

Basic information about this protein and its source genome.

Accession
KP13_05048
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ttdT AHE44778.1
Status
annotated
Amino acids
503
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
22.481
Human E-value
5.46e-07
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.807
Structure A0A0H3GSE8
Pocket Pocket 3
P2Rank 0.7
Structure A0A0H3GSE8
Pocket Pocket 1
ColabFold model
FPocket 0.935 · Pocket 5
P2Rank 0.675 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

49 records
Show feature table
Start End DB Term Name
154 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 109 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
439 461 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
69 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
458 476 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
304 320 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
439 457 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
240 250 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
477 499 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
476 498 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 503 PIRSF PIRSF002457 DASS
12 503 InterPro IPR030676 Citrate carrier CitT-related
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
387 408 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
111 133 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
209 239 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
326 345 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 502 Pfam PF00939 Sodium:sulfate symporter transmembrane region
26 502 InterPro IPR001898 Solute carrier family 13
381 386 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
327 346 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
347 357 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
110 133 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
44 48 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
49 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
500 503 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
304 321 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
209 231 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
358 380 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
276 303 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
414 432 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
134 153 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
24 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
73 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
321 326 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
49 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
358 380 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
251 275 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
409 413 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
390 412 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 501 PANTHER PTHR42826 DICARBOXYLATE TRANSPORTER 2.1, CHLOROPLASTIC
14 501 InterPro IPR030676 Citrate carrier CitT-related
41 498 NCBIfam TIGR00785 DASS family sodium-coupled anion symporter
41 498 InterPro IPR001898 Solute carrier family 13
67 72 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
433 438 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
251 273 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
173 208 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSE8
AlphaFold — — full sequence — Viewing
ColabFold KP13_05048
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.807
4 0.347

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.05 0.672
2 10.56 0.567
3 10.02 0.539
4 2.81 0.087
5 2.52 0.07

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
D10
6WU1
Q5FKK5 142.3 Da LogP 4.15 TPSA 0.0 ✓ Ro5 ✓ Clean CCCCCCCCCC
HEX
6WU1
Q5FKK5 86.2 Da LogP 2.59 TPSA 0.0 ✓ Ro5 ✓ Clean CCCCCC
OCT
6WU2
Q5FKK5 114.2 Da LogP 3.37 TPSA 0.0 ✓ Ro5 ✓ Clean CCCCCCCC

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.