Protein profile

KP13_03680

Protein BolA

Genome: KpKP13

Gene: bolA AHE46020.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJ55
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Amino acids 105
Annotations 3
Features 10
PDB binders 0
Druggability 0.557

Overview

Basic information about this protein and its source genome.

Accession
KP13_03680
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
bolA AHE46020.1
Status
annotated
Amino acids
105
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:1990229 A protein complex capable of assembling an iron-sulfur (Fe-S) cluster. GO:0006351 The synthesis of an RNA transcript from a DNA template.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
43.434
Human E-value
4.0199999999999993e-23
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.727
DEG E-value
6.09e-24
Localization
Cytoplasmic
ColabFold pLDDT
82.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.557
Structure A0A0H3GJ55
Pocket Pocket 2
P2Rank 0.179
Structure A0A0H3GJ55
Pocket Pocket 1
ColabFold model
FPocket 0.732 · Pocket 3
P2Rank 0.154 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 125 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:1990229 A protein complex capable of assembling an iron-sulfur (Fe-S) cluster.
  • GO:0006351 The synthesis of an RNA transcript from a DNA template.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 100 PIRSF PIRSF003113 BolA
1 100 InterPro IPR002634 BolA protein
1 90 Gene3D G3DSA:3.30.300.90 -
1 90 InterPro IPR036065 BolA-like superfamily
11 84 Pfam PF01722 BolA-like protein
11 84 InterPro IPR002634 BolA protein
1 89 SUPERFAMILY SSF82657 BolA-like
1 89 InterPro IPR036065 BolA-like superfamily
2 101 PANTHER PTHR46229 BOLA TRANSCRIPTION REGULATOR
2 89 FunFam G3DSA:3.30.300.90:FF:000001 Transcriptional regulator BolA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJ55
AlphaFold — — full sequence — Viewing
ColabFold KP13_03680
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.557
3 0.334

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.88 0.037