Protein profile

KP13_04130

Protein kinase-like domain-containing protein

Genome: KpKP13

Gene: AHE47479.1 Structure source: AlphaFold + ColabFold UniProt A0A024HVQ9
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Amino acids 499
Annotations 3
Features 11
PDB binders 0
Druggability 0.82

Overview

Basic information about this protein and its source genome.

Accession
KP13_04130
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47479.1
Status
annotated
Amino acids
499
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006468 The process of introducing a phosphate group on to a protein. GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.46

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.82
Structure A0A024HVQ9
Pocket Pocket 2
P2Rank 0.681
Structure A0A024HVQ9
Pocket Pocket 1
ColabFold model
FPocket 0.63 · Pocket 9
P2Rank 0.619 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 37 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0006468 The process of introducing a phosphate group on to a protein.
  • GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
167 179 ProSitePatterns PS00109 Tyrosine protein kinases specific active-site signature.
167 179 InterPro IPR008266 Tyrosine-protein kinase, active site
16 352 SMART SM00220 serkin_6
16 352 InterPro IPR000719 Protein kinase domain
105 349 Gene3D G3DSA:1.10.510.10 Transferase(Phosphotransferase) domain 1
154 269 Pfam PF00069 Protein kinase domain
154 269 InterPro IPR000719 Protein kinase domain
16 346 ProSiteProfiles PS50011 Protein kinase domain profile.
16 346 InterPro IPR000719 Protein kinase domain
146 268 SUPERFAMILY SSF56112 Protein kinase-like (PK-like)
146 268 InterPro IPR011009 Protein kinase-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A024HVQ9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04130
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.82

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.21 0.493
2 9.03 0.483
3 3.24 0.112
4 2.85 0.09
5 2.39 0.063