Target Pathogen

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Pockets High Medium Low

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #2

0.274

Unusual size

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Surrounding area

Site 2 FPocket #14

0.224

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.288

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Residue sets

UniProt: Active site:126-126 Proton donor

UniProt: Active site:162-162 Proton acceptor

UniProt: Active site:66-66 Nucleophile; acyl-ester intermediate

UniProt: Active site:69-69 Proton acceptor

UniProt: Binding site:126-126

UniProt: Binding site:162-162

UniProt: Binding site:69-69

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.926

Likely same site as P2Rank 1 3.8 Å 15 shared residues 88% of smaller site

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Surrounding area

Site 2 FPocket #2

0.327

Likely same site as P2Rank 1 3.7 Å 11 shared residues 92% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.842

Likely same site as FPocket 2 3.7 Å 11 shared residues 92% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.292

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.963

Likely same site as P2Rank 1 1.0 Å 20 shared residues 100% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.817

Likely same site as FPocket 1 1.0 Å 20 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.351

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.677

Likely same site as P2Rank 1 2.7 Å 13 shared residues 93% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.832

Likely same site as FPocket 1 2.7 Å 13 shared residues 93% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.572

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Surrounding area

Site 3 P2Rank #3

0.007

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Surrounding area

Site 4 P2Rank #4

0.004

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.951

Likely same site as P2Rank 1 4.0 Å 15 shared residues 88% of smaller site

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Surrounding area

Site 2 FPocket #3

0.35

Likely same site as P2Rank 1 4.2 Å 11 shared residues 85% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.849

Likely same site as FPocket 1 4.0 Å 15 shared residues 88% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.335

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.94

Likely same site as P2Rank 1 1.1 Å 20 shared residues 95% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.855

Likely same site as FPocket 1 1.1 Å 20 shared residues 95% of smaller site

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Site 2 P2Rank #2

0.513

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Surrounding area

Site 3 P2Rank #3

0.02

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Surrounding area

Site 4 P2Rank #4

0.003

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.94

Likely same site as P2Rank 1 0.7 Å 21 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.862

Likely same site as FPocket 1 0.7 Å 21 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.591

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Surrounding area

Site 3 P2Rank #3

0.012

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.996

Likely same site as P2Rank 1 2.3 Å 20 shared residues 95% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.855

Likely same site as FPocket 1 2.3 Å 20 shared residues 95% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.334

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.93

Likely same site as P2Rank 1 1.1 Å 20 shared residues 95% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.835

Likely same site as FPocket 1 1.1 Å 20 shared residues 95% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.456

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Surrounding area

Site 3 P2Rank #3

0.014

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.954

Likely same site as P2Rank 1 4.5 Å 15 shared residues 88% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.848

Likely same site as FPocket 1 4.5 Å 15 shared residues 88% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.349

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.972

Likely same site as P2Rank 2 1.0 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 FPocket #12

0.557

Likely same site as P2Rank 1 2.0 Å 17 shared residues 89% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.604

Likely same site as FPocket 12 2.0 Å 17 shared residues 89% of smaller site

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Site 2 P2Rank #2

0.254

Likely same site as FPocket 1 1.0 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 3 P2Rank #3

0.126

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Surrounding area

Site 4 P2Rank #4

0.053

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Surrounding area

Site 5 P2Rank #6

0.016

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #8

0.32

Likely same site as P2Rank 2 4.2 Å 22 shared residues 92% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.751

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Site 2 P2Rank #2

0.724

Likely same site as FPocket 8 4.2 Å 22 shared residues 92% of smaller site

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Surrounding area

Site 3 P2Rank #4

0.024

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.935

Likely same site as P2Rank 1 1.0 Å 20 shared residues 95% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.82

Likely same site as FPocket 1 1.0 Å 20 shared residues 95% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.188

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Surrounding area

Site 3 P2Rank #3

0.017

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.931

Likely same site as P2Rank 1 1.2 Å 21 shared residues 95% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.852

Likely same site as FPocket 1 1.2 Å 21 shared residues 95% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.327

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.923

Likely same site as P2Rank 1 3.4 Å 14 shared residues 93% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.819

Likely same site as FPocket 1 3.4 Å 14 shared residues 93% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.384

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Site 3 P2Rank #3

0.02

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.934

Likely same site as P2Rank 1 1.1 Å 21 shared residues 100% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.868

Likely same site as FPocket 1 1.1 Å 21 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.532

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Surrounding area

Site 3 P2Rank #3

0.018

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.992

Likely same site as P2Rank 1 1.2 Å 19 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.819

Likely same site as FPocket 1 1.2 Å 19 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.397

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.427

Likely same site as P2Rank 2 3.0 Å 12 shared residues 92% of smaller site

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Site 2 FPocket #2

0.411

Likely same site as P2Rank 3 3.4 Å 12 shared residues 80% of smaller site

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Site 3 FPocket #4

0.286

Likely same site as P2Rank 1 0.8 Å 19 shared residues 95% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.601

Likely same site as FPocket 4 0.8 Å 19 shared residues 95% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.337

Likely same site as FPocket 1 3.0 Å 12 shared residues 92% of smaller site

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Surrounding area

Site 3 P2Rank #3

0.127

Likely same site as FPocket 2 3.4 Å 12 shared residues 80% of smaller site

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Surrounding area

Site 4 P2Rank #4

0.022

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.972

Likely same site as P2Rank 2 4.6 Å 15 shared residues 88% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.485

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Site 2 P2Rank #2

0.364

Likely same site as FPocket 1 4.6 Å 15 shared residues 88% of smaller site

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Surrounding area

Site 3 P2Rank #3

0.178

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Surrounding area

Site 4 P2Rank #4

0.033

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Surrounding area

Site 5 P2Rank #5

0.025

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.919

Likely same site as P2Rank 1 0.8 Å 20 shared residues 100% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.82

Likely same site as FPocket 1 0.8 Å 20 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.272

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.989

Likely same site as P2Rank 1 1.4 Å 20 shared residues 95% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.763

Likely same site as FPocket 1 1.4 Å 20 shared residues 95% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.507

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.944

Likely same site as P2Rank 1 5.3 Å 14 shared residues 82% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.826

Likely same site as FPocket 1 5.3 Å 14 shared residues 82% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.381

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.923

Likely same site as P2Rank 1 3.3 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 FPocket #2

0.274

Likely same site as P2Rank 1 3.8 Å 11 shared residues 85% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.883

Likely same site as FPocket 1 3.3 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.395

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.925

Likely same site as P2Rank 1 3.5 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 FPocket #2

0.383

Likely same site as P2Rank 1 3.7 Å 11 shared residues 85% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.874

Likely same site as FPocket 1 3.5 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.398

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Site 3 P2Rank #3

0.006

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.403

Likely same site as P2Rank 3 2.1 Å 9 shared residues 90% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.633

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Surrounding area

Site 2 P2Rank #2

0.181

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Site 3 P2Rank #3

0.048

Likely same site as FPocket 1 2.1 Å 9 shared residues 90% of smaller site

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Surrounding area

Site 4 P2Rank #4

0.03

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Surrounding area

Site 5 P2Rank #5

0.022

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.982

Likely same site as P2Rank 1 1.9 Å 20 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.801

Likely same site as FPocket 1 1.9 Å 20 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.316

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.98

Likely same site as P2Rank 1 1.7 Å 19 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.779

Likely same site as FPocket 1 1.7 Å 19 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.266

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.916

Likely same site as P2Rank 1 1.3 Å 21 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.854

Likely same site as FPocket 1 1.3 Å 21 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.215

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Surrounding area

Site 3 P2Rank #3

0.078

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Surrounding area

Site 4 P2Rank #4

0.031

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Surrounding area

Site 5 P2Rank #5

0.005

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.924

Likely same site as P2Rank 1 1.5 Å 20 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.859

Likely same site as FPocket 1 1.5 Å 20 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.151

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Surrounding area

Site 3 P2Rank #3

0.052

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Surrounding area

Site 4 P2Rank #4

0.016

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.931

Likely same site as P2Rank 1 1.3 Å 21 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.836

Likely same site as FPocket 1 1.3 Å 21 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.497

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.907

Likely same site as P2Rank 1 3.6 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 FPocket #2

0.294

Likely same site as P2Rank 1 3.4 Å 11 shared residues 92% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.849

Likely same site as FPocket 2 3.4 Å 11 shared residues 92% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.372

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.928

Likely same site as P2Rank 1 1.0 Å 22 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.848

Likely same site as FPocket 1 1.0 Å 22 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.252

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Surrounding area

Site 3 P2Rank #3

0.006

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.965

Likely same site as P2Rank 1 5.3 Å 15 shared residues 88% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.866

Likely same site as FPocket 1 5.3 Å 15 shared residues 88% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.303

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.922

Likely same site as P2Rank 1 1.2 Å 21 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.86

Likely same site as FPocket 1 1.2 Å 21 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.395

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.924

Likely same site as P2Rank 1 3.1 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 FPocket #2

0.302

Likely same site as P2Rank 1 4.0 Å 11 shared residues 85% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.821

Likely same site as FPocket 1 3.1 Å 15 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.316

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Surrounding area

Site 3 P2Rank #3

0.007

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Surrounding area

Site 4 P2Rank #4

0.005

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.91

Likely same site as P2Rank 1 1.1 Å 20 shared residues 100% of smaller site

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.847

Likely same site as FPocket 1 1.1 Å 20 shared residues 100% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.277

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Surrounding area

Site 3 P2Rank #3

0.001

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Surrounding area

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.974

Likely same site as P2Rank 1 1.5 Å 19 shared residues 95% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.835

Likely same site as FPocket 1 1.5 Å 19 shared residues 95% of smaller site

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Site 2 P2Rank #2

0.246

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.894

Likely same site as P2Rank 1 3.6 Å 15 shared residues 100% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.855

Likely same site as FPocket 1 3.6 Å 15 shared residues 100% of smaller site

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Site 2 P2Rank #2

0.054

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.904

Likely same site as P2Rank 1 3.2 Å 14 shared residues 93% of smaller site

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Site 2 FPocket #2

0.319

Likely same site as P2Rank 1 3.8 Å 10 shared residues 77% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.871

Likely same site as FPocket 1 3.2 Å 14 shared residues 93% of smaller site

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Site 2 P2Rank #2

0.37

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.884

Likely same site as P2Rank 1 2.6 Å 15 shared residues 100% of smaller site

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Site 2 FPocket #2

0.356

Likely same site as P2Rank 1 4.4 Å 11 shared residues 85% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.849

Likely same site as FPocket 1 2.6 Å 15 shared residues 100% of smaller site

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Site 2 P2Rank #2

0.363

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Site 3 P2Rank #3

0.003

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.931

Likely same site as P2Rank 1 1.7 Å 22 shared residues 100% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.825

Likely same site as FPocket 1 1.7 Å 22 shared residues 100% of smaller site

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Site 2 P2Rank #2

0.368

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Site 3 P2Rank #3

0.008

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.896

Likely same site as P2Rank 1 1.2 Å 22 shared residues 100% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.85

Likely same site as FPocket 1 1.2 Å 22 shared residues 100% of smaller site

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Site 2 P2Rank #2

0.168

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Site 3 P2Rank #3

0.004

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.976

Likely same site as P2Rank 1 2.0 Å 20 shared residues 100% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.843

Likely same site as FPocket 1 2.0 Å 20 shared residues 100% of smaller site

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Site 2 P2Rank #2

0.362

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Site 3 P2Rank #3

0.004

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.962

Likely same site as P2Rank 1 4.8 Å 14 shared residues 78% of smaller site

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Site 2 FPocket #2

0.311

Likely same site as P2Rank 1 3.6 Å 11 shared residues 85% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.852

Likely same site as FPocket 2 3.6 Å 11 shared residues 85% of smaller site

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Site 2 P2Rank #2

0.316

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Site 3 P2Rank #3

0.017

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Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #1

0.903

Likely same site as P2Rank 1 3.9 Å 14 shared residues 93% of smaller site

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Site 2 FPocket #2

0.202

Likely same site as P2Rank 1 3.4 Å 11 shared residues 92% of smaller site

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.846

Likely same site as FPocket 2 3.4 Å 11 shared residues 92% of smaller site

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Site 2 P2Rank #2

0.433

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Site 3 P2Rank #3

0.032

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