Target Pathogen

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Pockets High Medium Low

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #40

0.654

Likely same site as P2Rank 3 6.7 Å 4 shared residues 50% of smaller site

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Site 2 FPocket #27

0.488

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.835

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Site 2 P2Rank #2

0.583

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Site 3 P2Rank #3

0.029

Likely same site as FPocket 40 6.7 Å 4 shared residues 50% of smaller site

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Site 4 P2Rank #4

0.022

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Site 5 P2Rank #5

0.014

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Residue sets

UniProt: Active site:379-379 Nucleophile; for glutamine hydrolysis

UniProt: Active site:515-515

UniProt: Active site:517-517

UniProt: Binding site:14-14

UniProt: Binding site:140-140

UniProt: Binding site:147-149

UniProt: Binding site:15-20

UniProt: Binding site:187-192

UniProt: Binding site:223-223

UniProt: Binding site:239-241

UniProt: Binding site:352-352

UniProt: Binding site:380-383

UniProt: Binding site:403-403

UniProt: Binding site:470-470

UniProt: Binding site:72-72

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #40

0.556

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.798

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Site 2 P2Rank #2

0.611

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Site 3 P2Rank #3

0.01

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