Target Pathogen

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Pockets High Medium Low

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #6

0.418

Likely same site as P2Rank 1 3.7 Å 12 shared residues 100% of smaller site

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Site 2 FPocket #20

0.27

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Site 3 FPocket #3

0.241

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Site 4 FPocket #22

0.225

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.829

Likely same site as FPocket 6 3.7 Å 12 shared residues 100% of smaller site

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Site 2 P2Rank #2

0.055

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Site 3 P2Rank #3

0.014

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Site 4 P2Rank #4

0.001

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Residue sets

UniProt: Binding site:121-121

UniProt: Binding site:125-127

UniProt: Binding site:246-246

UniProt: Binding site:355-357

UniProt: Site:228-228 Plays an important role in substrate specificity

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #7

0.449

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Site 2 FPocket #28

0.308

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.727

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Site 2 P2Rank #2

0.098

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Site 3 P2Rank #3

0.045

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Site 4 P2Rank #4

0.015

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