Target Pathogen

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Pockets High Medium Low

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #23

0.943

Unusual size

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Surrounding area

Site 2 FPocket #5

0.339

Likely same site as P2Rank 1 2.5 Å 34 shared residues 87% of smaller site

Unusual size

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Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.986

Likely same site as FPocket 5 2.5 Å 34 shared residues 87% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.107

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Site 3 P2Rank #3

0.078

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Surrounding area

Site 4 P2Rank #4

0.021

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Residue sets

UniProt: Active site:106-106 Proton donor

UniProt: Binding site:106-106

UniProt: Binding site:108-110

UniProt: Binding site:145-145

UniProt: Binding site:175-175

UniProt: Binding site:258-260

UniProt: Binding site:92-92

UniProt: Binding site:96-96

UniProt: Site:175-175 Important for dimerization

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #20

0.553

Likely same site as P2Rank 1 1.7 Å 45 shared residues 96% of smaller site

Unusual size

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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1

0.987

Likely same site as FPocket 20 1.7 Å 45 shared residues 96% of smaller site

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Surrounding area

Site 2 P2Rank #2

0.093

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Site 3 P2Rank #3

0.033

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Site 4 P2Rank #4

0.031

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Site 5 P2Rank #5

0.002

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Surrounding area