Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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15 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 2.3.1.1

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EC Number: 2.3.1.1 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_1372 beta-ketoacyl-acyl-carrier-protein synthase II fabF AlphaFold + ColabFold
2.3.1.179
GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +25 total
0.967 Hit 44.2% 3.04e-112
2 VK055_4299 amino-acid N-acetyltransferase argA AlphaFold + ColabFold
2.3.1.1
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.919 No Hit 0.0% —
3 VK055_0599 arylamine N-acetyltransferase AlphaFold + ColabFold
2.3.1.118
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0004060Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. GO:0046990Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine.
0.87 Hit 26.0% 3.39e-16
4 VK055_3136 acetyl-CoA C-acyltransferase FadA fadA AlphaFold + ColabFold
2.3.1.16
GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +58 total
0.843 Hit 45.2% 9.40e-71
5 VK055_2451 dihydrolipoyllysine-residue acetyltransferase aceF AlphaFold + ColabFold
2.3.1.12
GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0045254A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. +47 total
0.84 Hit 36.0% 1.91e-26
6 VK055_1032 3-oxoadipyl-CoA thiolase pcaF2 AlphaFold + ColabFold
2.3.1.174
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +14 total
0.801 Hit 47.5% 6.60e-60
7 VK055_0712 beta-ketoacyl-acyl-carrier-protein synthase II fabF2 AlphaFold + ColabFold
2.3.1.179
GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +25 total
0.799 Hit 45.8% 1.28e-10
8 VK055_4789 acetyl-CoA C-acyltransferase FadI fadI AlphaFold + ColabFold
2.3.1.16
GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +58 total
0.76 Hit 47.8% 7.17e-59
9 VK055_1870 lipoyl(octanoyl) transferase lipB AlphaFold + ColabFold
2.3.1.181
GO:0033819Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]. GO:0009249The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). +14 total
0.738 Hit 40.3% 1.95e-13
10 VK055_2373 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase lpxD AlphaFold + ColabFold
2.3.1.191
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016410Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. +36 total
0.707 No Hit 0.0% —
11 VK055_0963 3-oxoadipyl-CoA thiolase pcaF AlphaFold + ColabFold
2.3.1.174
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +14 total
0.704 Hit 46.4% 8.63e-53
12 VK055_2371 acyl-[acyl-carrier-protein]-UDP-N- acetylglucosamine O-acyltransferase lpxA AlphaFold + ColabFold
2.3.1.129
GO:0008780Catalysis of the reaction: a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]. GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +36 total
0.561 No Hit 0.0% —
13 VK055_2386 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD AlphaFold + ColabFold
2.3.1.117
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0008666Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA. +36 total
0.532 No Hit 0.0% —
14 VK055_1015 arginine N-succinyltransferase astA AlphaFold + ColabFold
2.3.1.109
GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0008791Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.
0.265 No Hit 0.0% —
15 VK055_4703 tRNAMet cytidine acetyltransferase AlphaFold + ColabFold
2.3.1.193
GO:0051392Catalysis of the reaction: a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N4-acetylcytidine in tRNA + CoA + H+ + phosphate. GO:0002101The process in which a cytosine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +710 total
0.245 Hit 23.4% 2.04e-17
Page 1 of 1 · 15 total proteins