Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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4 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 2.4.99.28

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EC Number: 2.4.99.28 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_1866 rod shape-determining protein RodA mrdB AlphaFold + ColabFold
2.4.99.28
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0008360Any process that modulates the surface configuration of a cell. +69 total
0.951 No Hit 0.0% —
2 VK055_2479 cell division protein FtsW ftsW AlphaFold + ColabFold
2.4.99.28
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +710 total
0.835 No Hit 0.0% —
3 VK055_4651 penicillin-binding protein 1C pbpC AlphaFold + ColabFold
2.4.99.28
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0008955Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +36 total
0.635 No Hit 0.0% —
4 VK055_3704 peptidoglycan synthetase penicillin-binding protein 1A AlphaFold + ColabFold
2.4.99.28 3.4.16.4
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
0.568 No Hit 0.0% —
Page 1 of 1 · 4 total proteins