Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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Sorted by Druggability (descending)

Applied filters EC Number: 2.7.1.15

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EC Number: 2.7.1.15 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_0768 pfkB carbohydrate kinase family protein AlphaFold DB model + ColabFold model
2.7.1.15
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004747Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate.
No map 0.767 Hit 29.9% 5.86e-11
2 VK055_4343 cobU cobU Experimental + ColabFold model
2.7.1.156 2.7.7.62
GO:0043752Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP). GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +36 total
Chokepoint 5 0.345 No Hit 0.0% —
3 VK055_0446 pfkB carbohydrate kinase family protein AlphaFold DB model + ColabFold model
2.7.1.15
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006014The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. GO:0004747Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. +47 total
No map 0.15 Hit 35.4% 1.14e-40
Page 1 of 1 · 3 total proteins