Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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4 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 3.1.2.2

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Active criteria 1
EC Number: 3.1.2.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_2076 tesA tesA AlphaFold + ColabFold
3.1.1.2 3.1.1.5 3.1.2.14 +14 total
GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0016298Catalysis of the hydrolysis of a lipid. GO:0004064Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. +25 total
0.633 No Hit 0.0% —
2 VK055_2137 acyl-CoA thioesterase II tesB AlphaFold + ColabFold
3.1.2.20
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. GO:0006637The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.359 Hit 50.0% 1.30e-07
3 VK055_0301 proofreading thioesterase in enterobactin biosynthesis ybdB AlphaFold + ColabFold
3.1.2.28
GO:0061522Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+. GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.273 No Hit 0.0% —
4 VK055_3160 hypothetical protein AlphaFold + ColabFold
3.1.2.20
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
0.195 No Hit 0.0% —
Page 1 of 1 · 4 total proteins