Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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3 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 3.1.3.7

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EC Number: 3.1.3.7 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_1889 2,3-diketo-5-methylthio-1-phosphopentane phosphatase mtnC AlphaFold + ColabFold
3.1.3.77
GO:0043874Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. +25 total
0.83 Hit 50.0% 8.59e-41
2 VK055_2855 3'(2'),5'-bisphosphate nucleotidase cysQ AlphaFold + ColabFold
3.1.3.7
GO:0008441Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0046854The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. +47 total
0.559 Hit 33.3% 1.53e-08
3 VK055_1862 alpha-ribazole phosphatase cobC AlphaFold + ColabFold
3.1.3.73
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016868Catalysis of the transfer of a phosphate group from one position to another within a single molecule. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +69 total
0.52 Hit 29.8% 3.94e-11
Page 1 of 1 · 3 total proteins