Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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6 / 5081 proteins

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Sorted by Druggability (descending)

Applied filters EC Number: 3.5.1.1

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EC Number: 3.5.1.1 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_1440 pyrimidine utilization protein B rutB AlphaFold DB model + ColabFold model
3.5.1.110
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0019740A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. GO:0006212The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
No map 0.608 No Hit 0.0% —
2 VK055_3230 acetylornithine deacetylase argE AlphaFold DB model + ColabFold model
3.5.1.16
GO:0019213Catalysis of the hydrolysis of an acetyl group from a substrate molecule. GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +36 total
Mapped 2 0.583 No Hit 0.0% —
3 VK055_4706 succinyl-diaminopimelate desuccinylase dapE AlphaFold DB model + ColabFold model
3.5.1.18
GO:0009014Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +58 total
Chokepoint 1 0.44 Hit 42.9% 3.10e-07
4 VK055_0761 peptidase, ArgE/DapE family protein AlphaFold DB model + ColabFold model
3.5.1.18
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009014Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate. +14 total
No map 0.416 Hit 23.6% 5.24e-09
5 VK055_0246 formyltetrahydrofolate deformylase purU AlphaFold DB model + ColabFold model
3.5.1.10
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0008864Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+. +14 total
Mapped 1 0.407 Hit 32.9% 2.06e-16
6 VK055_1256 L-asparaginase I AlphaFold DB model + ColabFold model
3.5.1.1
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004067Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH4+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
Mapped 2 0.178 Hit 58.6% 6.13e-34
Page 1 of 1 · 6 total proteins