Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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7 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 4.2.1.2

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EC Number: 4.2.1.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_1196 tryptophan synthase, beta subunit trpB AlphaFold + ColabFold
4.2.1.20
GO:0004834Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. GO:0006568The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. +14 total
0.945 No Hit 0.0% —
2 VK055_0988 fumarate hydratase, class II fumC AlphaFold + ColabFold
4.2.1.2
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006106The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. GO:0045239Any of the heteromeric enzymes that act in the TCA cycle. +69 total
0.806 Hit 61.9% 2.48e-175
3 VK055_3982 glycerol dehydrase beta subunit gldB Experimental + ColabFold
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
0.803 No Hit 0.0% —
4 VK055_0329 hypothetical protein AlphaFold + ColabFold
4.2.1.2
GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O.
0.721 No Hit 0.0% —
5 VK055_3983 glycerol dehydrase gamma subunit dhaB3 Experimental + ColabFold
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
0.695 No Hit 0.0% —
6 VK055_0957 fumarase A fumA2 AlphaFold + ColabFold
4.2.1.2
GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0006091The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. +58 total
0.481 No Hit 0.0% —
7 VK055_2240 porphobilinogen synthase hemB AlphaFold + ColabFold
4.2.1.24
GO:0004655Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0046872Binding to a metal ion. +36 total
0.454 Hit 42.4% 3.93e-76
Page 1 of 1 · 7 total proteins